The purpose of this article is to examine the gender issue by emphasizing ontology, anthropology, and epistemology of Mulla Sadra. Although Mulla Sadra did not directly address the gender issue, but considering its ontological, human-cognitive and epistemological foundations, he can refer to some of the hidden layers of this wise thought in this field of radiation Throw The ontological-semantic attitude of gender (femininity and masculinity) is not based on the originality of existence and the only and only existential level of existence among humans is assumed. Man has the same essence as other beings and extends from the lowest to the full extent of power. In this conversion and intriguing transformation femininity and masculinity are not conceivable. On the basis of the human's anthropology, gender does not share the identity and truth of man, and these characteristics and distinctions are beyond the limits of humanity. In the epistemology section, according to Mulla Sadra, human beings are not at the same time in terms of knowing one's knowledge, but everyone has a degree of knowing. But the difference in degrees of knowledge lies in the difference in the level of the existential of individuals, not their gender. In fact, femininity and masculinity are the characteristics of nature and body, as is the case in plants and animals.